Bottle and box of eSHa NDX, 20 ml, a dewormer against nematodes in fish

Internal parasites of aquarium fish: Camallanus, Capillaria and Oxyuris nematodes

eSHa NDX dewormer against fish nematodes

Name: eSHa NDX dewormer against fish nematodes
Brand: eSHa
SKU: ESHA-NDX-20ML
Price: 13.9 EUR
Availability: InStock

13,90 €

This levamisole dewormer treats roundworms in the digestive tract of ornamental fish, in both freshwater and seawater. The course consists of one drop per litre in a single application, a 50% water change 24 hours later and a second dose 14 days after the first.

A 20 ml bottle treats 450 litres, and plants and shrimps tolerate the course well.

Ref. ESHA-NDX-20ML·Aquarium medication

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The summary

What you receive: a 20 ml dropper bottle with its instructions for use.
What it targets: roundworms of the digestive tract, including Camallanus, in freshwater and saltwater alike.
The protocol: one dose, a 50% water change 24 hours later, then the same again 14 days after.
What one bottle covers: one dose for 450 litres at one drop per litre, or the full two-dose course for 225 litres.
Before you start: remove the activated carbon from the filter and prepare the water for the change.
Shipping: small bottle sent by tracked parcel, costs calculated at checkout.

Levamisole dewormer, one dose and a water change, to be repeated 14 days later

eSHa NDX Wormer is a levamisole treatment for roundworms in the digestive tract of ornamental fish, including Camallanus, in freshwater and in seawater. It is given at the rate of one drop per litre, followed by a 50% water change the next day, then a second dose 14 days later. A 20 ml bottle covers one dose for 450 litres, or the full course of two doses for 225 litres.

This dropper bottle is a wormer containing levamisole, intended for roundworms living in the digestive tract of ornamental fish. It is given only once, followed by a water change the next day, and the same dose is repeated 14 days later. A 20 ml bottle covers one dose for 450 litres, so the full course of two doses for 225 litres, in freshwater as in seawater, where the treatment should be carried out in a quarantine tank.

🪱 The worms targeted

The common thread

A red filament protruding from the vent is the most recognisable sign of a Camallanus infestation.

The fish that is losing weight

The fish eats normally and yet loses weight, because the worms take a share of what it digests.

On an empty stomach

The abdomen hollows, the back becomes prominent and the swimming slows down.

💧 The dose and the next day

The dose is one drop per litre of water, calculated on the net volume of the tank and added in one go: 100 drops come to 4.4 ml. Beforehand, remove the activated carbon and resins from the filter, which would absorb the product, and do not feed your fish that day. An aquarium air pump running for the following 24 hours keeps the water well oxygenated. The next day, siphon the bottom, rinse the filter and change half of the volume with water prepared in advance and at the same temperature. In saltwater, the protein skimmer is switched off for the first 4 hours and the UV lamp for the first 24.

The next day's water change is part of the treatment

The worms paralysed by the dose are expelled alive and end up on the bottom of the tank, from where only siphoning and a water change will remove them. So siphon the substrate 24 hours later, then change half of the water.

Fresh activated carbon to finish off each dose

The activated carbon for aquarium filters removes what remains of the wormer once the dose has run its course. Placed in the filter after the next day's water change, it lets you make do with a 20% water change when half the volume is hard to prepare. Allow enough for both doses, since carbon that is already saturated no longer retains anything and has to be replaced each time.

The first dose reaches the adult worms, but not the eggs that the females have already released. For egg-laying species, the same dose is therefore repeated 14 days after the first, with the same siphoning and the same water change the next day, in order to reach the worms that have hatched in the meantime. In stubborn cases, a third round can follow 2 weeks later. Note the dates on a calendar on the day you begin, because a course stopped after the first dose lets the population build up again.

🐠 Which fish can live in the tank

The treatment is well tolerated by freshwater and marine fish, by plants and by your shrimps, and your snails can stay in the tank. Corals, anemones and sea urchins are more sensitive: in a reef tank, you should therefore always treat the fish in a quarantine tank. Carry out this treatment with no other medication in the tank, since the water change and the carbon the following day also remove any added product. A fish that scratches itself without showing any filament is more likely a case for the treatment for skin and gill worms, to be given separately.

🌱 A separate tank in aquaponics

In aquaponics, fish are also treated separately, for a different reason. The product is intended for ornamental fish and excludes animals raised for consumption, and two 50% water changes cannot be carried out in a loop that waters crops. So you move the affected ornamental fish to a treatment tank, where it receives its two doses and its two water changes, then you return it to the system. The article on fish welfare describes how to set up this quarantine tank.

Technical specifications

The essentials

Dose: 1 drop per litreAll at once, based on the net volume. 100 drops make 4.4 ml.
Volume treated: 450 L per dose, 225 L per full courseTwo doses 14 days apart, one drop per litre each time.

The calendar

24 hours later: Siphoning, filter, 50% water changeOr 20% followed by filtration through fresh activated carbon.
Second dose: 14 days after the firstIt reaches the worms that have hatched since the first dose.

During the treatment

Active ingredient: Levamisole
Shrimp and snails: Can stay in the tankIn a reef tank, fish are treated separately, away from the corals, anemones and sea urchins.

To budget for separately

Replacement water: Half the volume, twiceTo be prepared in advance and at the same temperature as the tank.
Fresh activated carbon: One load per dose

In the box

1 dropper bottle of 20 ml
1 instruction leaflet

Doses, course schedule, volumes and tolerances taken from the eSHa instructions for use, on 19/09 and 11/10/2026. Directions for use taken from the same leaflet.

Manufacturer and product safety

Manufacturer: Sea Horse IPC B.V. (eSHa Labs)
Postal address: Hertog van Brabantlaan 4, 6223 CJ Maastricht, Pays-Bas (boîte postale : Postbus 431, 6200 AK Maastricht)
Contact: contact@eshalabs.com
Website: eshalabs.com

Information provided under Regulation (EU) 2023/988 on general product safety.

A worm in the gut, a worm on the skin

The two treatments are not alike: a single dose with a water change on one side, 3 days of dosing on the other.

The worm may or may not be visible A protruding filament and a fish that rubs itself call for neither the same bottle nor the same schedule.

	Where it attaches	What you see	Also effective against tapeworms	Dosing days (days)	Litres treated per 20 ml bottle, full course (L)	Change half of the water 24 hours afterwards	Second treatment 14 days later	Price
Recommended eSHa NDX dewormer against fish nematodesYour choice	In the gut	A red thread hanging from the vent	No	1 days	225 L	Yes	Yes	13,90 €
eSHa GDEX treatment against skin and gillYour choice	On the skin and in the gills	Rubbing, swollen gills, rapid breathing	Yes	3 days	300 L	No	No	13,90 €

eSHa NDX dewormer against fish nematodesRecommended

The worm you are looking for

Where it attachesIn the gut

What you seeA red thread hanging from the vent

Also effective against tapewormsNo

The protocol

Dosing days (days)1 days

Litres treated per 20 ml bottle, full course (L)225 L

Change half of the water 24 hours afterwardsYes

Second treatment 14 days laterYes

In the shop

eSHa GDEX treatment against skin and gill

The worm you are looking for

Where it attachesOn the skin and in the gills

What you seeRubbing, swollen gills, rapid breathing

Also effective against tapewormsYes

The protocol

Dosing days (days)3 days

Litres treated per 20 ml bottle, full course (L)300 L

Change half of the water 24 hours afterwardsNo

Second treatment 14 days laterNo

In the shop

Doses, treatment durations, bottle capacities and tolerances recorded from the eSHa instructions for use, on 19/09 and 11/10/2026.

Estimate your
delivery time

Small bottle shipped by tracked parcel from France. The exact shipping costs and delivery times are shown in your basket once you have entered your address. Outside the European Union, import duties and taxes are payable by the recipient. Once unsealed, this product cannot be returned under the right of withdrawal (article L221-28, 5° of the French Consumer Code), for reasons of hygiene and health protection.

Frequently asked questions

6 questions

6 key questions

How many drops for my tank?

Why is a water change compulsory?

Because the expelled worms end up alive on the bottom of the tank. Leaving them there undoes what the dose has just achieved.

24 hours after the dose, siphon the substrate, clean the filter and change half the volume, or only 20% if you then filter through fresh activated carbon. Prepare this water in advance, at the same temperature, to avoid a thermal shock on top of the treatment.

Can the second dose be skipped if everything is going well?

What should you do about shrimp and snails?

Does this protocol hold up in aquaponics?

No, and for two reasons that add up. The use is intended for ornamental fish and excludes animals raised for consumption; and the protocol calls for changing half the volume after each of the two doses, which would destabilise your crops.

An affected ornamental fish can be moved to a treatment tank, where it receives its two doses and undergoes its two water changes, then returns. You treat a few dozen litres instead of several hundred.

How should I manage the days that follow?

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eSHa NDX dewormer against fish nematodes

The summary