Everything comes down to a single criterion: the mobility of the element within the plant. A mobile element is relocated from older leaves to new growth when it becomes scarce, so symptoms appear lower down. An immobile element stays wherever it was first deposited, so symptoms appear higher up, on the youngest tissue.
In practice, yellowing that starts on young leaves with veins that remain clearly green points to iron deficiency. Yellowing between the veins of older leaves points to magnesium. Even, general yellowing of older leaves combined with noticeably slow growth points to nitrogen. The extension guides on iron chlorosis also describe a typical progression, where the veins themselves eventually fade, followed by brown spots appearing before necrosis sets in.
One further indicator helps to distinguish causes in aquaponics. Nitrogen is rarely the limiting factor in a system with a good fish load, since most of the nitrogen from the feed ends up in the water, with only a small fraction retained by the fish themselves. A nitrogen-like symptom in a well-fed system should therefore prompt you to look elsewhere, at root oxygenation or at a pH level that is blocking nutrient uptake.